The Bioorganic Chemistry Laboratory led by Prof. Qingxiang Guo works on the molecular recognition, electron transfer reactions in supramolecular systems and green chemistry. The research projects are supported by the Ministry of Science and Technology (MOST), the CAS, the Ministry of Education and the National Science Foundation of China (NSFC).
Employing experimental and theoretical methods, such as artificial neural networks and genetic algorithm, researchers in the lab predicted the driving forces and composition of driving forces for the molecular recognition of cyclodextrins. The binding constants for the inclusion complexation of cyclodextrins with substartes calculated were closed to the experimental data (J. Phys. Chem. B, 1999).

Enthalpy-entropy compensation effect was observed widely existent in the chemical and biological process. They studied the enthalpy-entropy compensation in protein unfolding and molecular recognition of cyclodextrin and suggested a new model for enthalpy-entropy compensation with a huge amount of experimental parameters and theoretical analysis (Chem. Rew. 2002).

They designed and synthesized some electron-accepting receptors with cyclodextrin as the framework. Supramolecular systems of the receptor with electron-donating substrates, such as naphthalene derivatives was formed by the host-guest interaction. The high efficient photoinduced elctron transfer reaction in the supramolecular system was observed in the lab (J. Org. Chem. 2002).